Esketamine Spravato®Therapy

Care that listens deeply, treatment that moves you forward. Thoughtfully guided support for a steadier mind.

About Our Spravato®Therapy Treatment

Depression is a stubborn disorder that takes a lot to clear out. When it does not go away that easily, it can feel exhausting, draining, isolating and discouraging. When depression doesn’t go away, there happens the need to use a much advanced tool to treat it. Spravato® (esketamine) therapy is for the individuals who do not respond to the traditional antidepressant methods. At Gainesville Psychiatry, we provide Spravato® in a very carefully monitored and supporting medical setting where every step towards care is guided with compassion, precision, safety and security.  

Spravato® creates a meaningful shift in how certain types of depression are treated, providing a renewed faith and possibility when the progress has felt limited. 

About Our Spravato Therapy Treatment
What Is Spravato (Esketamine)_

What Is Spravato® (Esketamine)?

Spravato® is an FDA approved nasal spray medication used for the treatment of treatment resistant depression and for certain cases of major depressive disorder with acute suicidal thoughts or ideation. It contains esketamine, a refined form of ketamine developed specifically for therapeutic use only under strict medical supervision. 

Spravato® acts on the brain’s glutamate system. It’s closely linked to mood regulation, cognition and neural connectivity. Other antidepressants primarily target serotonin and norepinephrine. Spravato® can help regain the lost communication between brain cells affected by severe depression. 

What Is Spravato (Esketamine)_

How Spravato® Works  

Depression can disrupt the brain’s ability to function properly and to form and maintain healthy neural connections. Spravato® works effectively different by: 

  • Empowering neural communication
  • Supporting brain plasticity and adaptability
  • Eliminating depressive symptoms more rapidly than the traditional medications for some individuals

Here at Gainesville Psychiatry, treatment is administered on site followed by a required observation period to ensure safety and response. 

How Spravato Works  

When is Spravato® Treatment Considered 

Spravato® cannot be used as a front line treatment. Spravato® is only used when depression remains untreated and severe despite using the traditional antidepressant methods and appropriate and continuous care.

Treatment Resistant Depression_ 

Treatment Resistant Depression: 

Individuals with inadequate response to multiple antidepressants and traditional treatments for depression. 

Functional Impairment_ 

Functional Impairment: 

Individuals who experience persistent, functionally impairing depressive symptoms.

When is Spravato Treatment Considered 
Critical Need_ 

Critical Need: 

Individuals needing rapid symptom relief due to the severity of the condition.

Treatment Plateau_

Treatment Plateau:

Individuals who have reached a plateau despite medication and psychotherapy. 

Why Accurate Treatment Matters 

Why Accurate Treatment Matters 

Precision is mandatory when it comes to using advanced treatment methods. Here at Gainesville Psychiatry, we provide careful assessment to make sure that the Spravato® Treatment is used responsibly and effectively. Precise treatment planning permits us to: 

Why Accurate Treatment Matters 01

Confirm suitability based on clinical history and current symptoms 

Why Accurate Treatment Matters 02

Observe and monitor symptoms and adjust the treatment accordingly

Why Accurate Treatment Matters 03

Integrate Spravato® into a broader, long term treatment strategy

Why Accurate Treatment Matters 04

Prioritise safety and security while enhancing therapeutic benefit 

Spravato As Part of Comprehensive Care

Spravato® As Part of Comprehensive Care 

Spravato® can be at its best effectiveness when it is incorporated into a well coordinated mental health plan. This treatment is typically paired with: 

  • An oral antidepressant 
  • Ongoing psychotherapy 
  • Regular psychiatric follow up

This integrated model helps stabilise the symptoms while empowering deeper emotional healing and long term resilience.  

Safety and Monitoring 

Spravato® is administered under the FDA mandated REMS (Risk Evaluation and Mitigation Strategy) program. This ensures: 

Treatments only takes place in certified medical settings Patients are properly monitored during and after the administration Side effects such as dissociation or blood pressure fluctuations are addressed promptly

Here, we make sure that the Spravato® treatment is not being used at home or being self administered outside the clinic. 

Safety and Monitoring 
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Get started towards healing with compassion and care with us.

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Frequently Asked Questions